/* Patient navigation and readable layouts shared by static and account pages. */
:root { font-size: 16px; }
html { scroll-padding-top: 24px; -webkit-text-size-adjust: 100%; }
body { overflow-wrap: break-word; }
input, select, button { font-size: 16px; }
:focus-visible { outline: 3px solid #a86218; outline-offset: 3px; }
.nav-toggle { display: none; }
.site-header nav > a, .card-actions a, .pagination a { min-height: 44px; display: inline-flex; align-items: center; }
.brand small, .site-footer p, .filing-links { font-size: 14px; }
.site-footer a { color: #bfe8e0; }
.eyebrow { font-size: 14px; letter-spacing: .05em; }
.public-hero { padding: 56px 0 40px; }
.hero-grid { grid-template-columns: minmax(0, 1fr) 310px; gap: 48px; }
.public-hero h1 { font-size: clamp(32px, 4vw, 48px); line-height: 1.3; }
.home-search { display: grid; grid-template-columns: minmax(0, 1fr) 170px; gap: 12px; margin-top: 24px; }
.home-search label, .topic-search-form label { display: grid; gap: 6px; font-size: 14px; font-weight: 600; }
.home-search input, .home-search select, .topic-search-form select { width: 100%; min-width: 0; min-height: 48px; padding: 10px 12px; border: 1px solid #b7c9ca; border-radius: 8px; color: var(--ink); background: white; }
.home-search .button { grid-column: 1 / -1; }
.home-shortcuts { display: flex; gap: 18px; flex-wrap: wrap; margin-top: 12px; font-size: 14px; }
.home-shortcuts a { min-height: 44px; display: inline-flex; align-items: center; }
.snapshot-card { padding: 24px; box-shadow: none; }
.snapshot-card > strong { font-size: 27px; }
.snapshot-card > span, .snapshot-card > p, .snapshot-card dt { font-size: 14px; }
.snapshot-card dl { grid-template-columns: 1fr 1fr; }
.browse-hub { padding: 48px 0; }
.browse-hub-head { margin-bottom: 24px; gap: 30px; }
.disease-card small, .drug-list span, .region-list span, .subtopic-card small { font-size: 14px; }
.disease-card-index { display: none; }
.disease-card { grid-template-columns: 1fr auto; min-height: 88px; padding: 17px; }
.region-browse-section, .drug-browse-section { padding: 44px 0; }
.region-list { grid-template-columns: repeat(3, minmax(0, 1fr)); }
.topic-hero { padding: 30px 0; }
.topic-hero-grid { grid-template-columns: minmax(0, 1fr) 440px; gap: 28px; }
.topic-hero h1 { font-size: 36px; }
.topic-summary dt, .topic-side-nav small, .topic-sidebar-head a { font-size: 14px; }
.topic-summary dd { font-size: 22px; }
.topic-layout { gap: 28px; padding-top: 28px; }
.topic-side-nav a { min-height: 44px; font-size: 14px; }
.topic-search-card { margin: 0; grid-template-columns: 1fr; gap: 20px; padding: 24px; }
.topic-search-card p { font-size: 14px; }
.topic-search-form { grid-template-columns: minmax(0,1fr) 170px auto; align-items: end; }
.topic-search-form label { color: #dbecea; }
.topic-search-form input, .topic-search-form select { min-height: 48px; }
.topic-block { margin-top: 28px; }
.topic-block-head h2, .records-head h2 { font-size: 25px; }
.topic-block-head p, .records-head p { font-size: 14px; }
.subtopic-grid { grid-template-columns: repeat(3, minmax(0, 1fr)); gap: 10px; margin-top: 16px; }
.subtopic-card { min-height: 78px; padding: 14px; }
.subtopic-card strong { font-size: 16px; }
.more-topics .subtopic-grid { padding: 0 12px 12px; }
.classification-disclosure { margin-top: 24px; }
.classification-disclosure p { padding: 0 16px 12px; font-size: 14px; color: var(--muted); }
.topic-records { margin-top: 28px; }
.result-meta, .result-card dt, .record-link { font-size: 14px; }
.result-card dd { font-size: 16px; line-height: 1.7; }
.result-card h3 { line-height: 1.5; }
.result-card { min-width: 0; }
.result-card dd, .result-card h3 { overflow-wrap: anywhere; }
.result-meta { flex-wrap: wrap; }
.record-link { min-height: 44px; align-items: center; display: inline-flex; }
.search-hero { padding: 36px 0; }
.search-hero h1 { font-size: 34px; }
.search-filter-group label, .search-form label, .filter-help, .quota-note { font-size: 14px; }
.advanced-filters { border: 0; margin-bottom: 0; }
.advanced-filters summary { border-radius: 8px; padding: 14px; font-size: 15px; }
.advanced-filters .search-filter-group { padding: 18px 0 0; }
.advanced-filters legend { display: none; }
.search-scope { margin: 0 0 18px; color: var(--teal); }
.active-filters { display: flex; align-items: center; gap: 8px; flex-wrap: wrap; margin-bottom: 20px; font-size: 14px; }
.active-filters strong { padding: 6px 10px; background: var(--soft); border-radius: 6px; font-weight: 500; overflow-wrap: anywhere; }
.active-filters a { padding: 10px; }
.matched-site { display: block; margin-bottom: 4px; }
.pagination a { border: 1px solid var(--line); padding: 8px 14px; border-radius: 8px; }
.download-file-meta { padding: 12px 16px; background: var(--soft); border-radius: 8px; font-weight: 600; }
.page-section h1 { font-size: 36px; overflow-wrap: anywhere; }
.detail-quick-actions { display: flex; flex-wrap: wrap; align-items: center; gap: 12px; margin-top: 24px; }
.detail-quick-actions > a:not(.button) { color: #d3f2ee; padding: 10px 0; }
.trial-detail-page .hero-facts dt, .trial-detail-page .fact-grid dt,
.trial-detail-page .date-grid dt, .trial-detail-page .site-list span,
.trial-detail-page .location-chips span, .trial-detail-page summary small,
.trial-detail-page .section-intro, .trial-detail-page .snapshot-warning p,
.trial-detail-page .snapshot-warning a, .trial-detail-page .aside-card p,
.trial-detail-page .quota-badge span, .trial-detail-page .patient-path,
.trial-detail-page .patient-path ol, .trial-detail-page .patient-path > strong { font-size: 14px; }
.trial-detail-page .fact-grid dd, .trial-detail-page .prose, .trial-detail-page .lead-prose { font-size: 16px; }
.trial-detail-page .hero-facts dd { font-size: 16px; }
.trial-detail-page .detail-head h1 { font-size: 34px; }
.trial-detail-page .aside-card .button { font-size: 16px; }
.trial-detail-page .source-table { overflow-wrap: anywhere; }
@media (max-width: 980px) {
  .hero-grid, .topic-hero-grid { grid-template-columns: 1fr; gap: 24px; }
  .snapshot-card { display: grid; grid-template-columns: 1fr auto; column-gap: 24px; }
  .snapshot-card > span { grid-column: 1; }
  .snapshot-card > strong { grid-column: 1; font-size: 22px; }
  .snapshot-card > p { grid-column: 1; margin: 4px 0 0; }
  .snapshot-card dl { grid-column: 2; grid-row: 1 / 4; margin: 0; gap: 20px; align-self: center; }
  .topic-summary { grid-template-columns: 1fr 1fr 1.35fr; max-width: none; }
  .topic-summary div:last-child { grid-column: auto; border-top: 0; }
  .topic-layout { grid-template-columns: 1fr; }
  .topic-side-nav { display: flex; overflow-x: auto; scrollbar-width: thin; }
  .topic-side-nav a { flex: 0 0 auto; }
}
@media (max-width: 700px) {
  .shell, .trial-detail-page .shell { width: calc(100% - 32px); }
  .site-header { height: auto; min-height: 66px; }
  .nav-row { min-height: 66px; flex-wrap: wrap; gap: 0 12px; }
  .brand { gap: 9px; }
  .brand strong { font-size: 15px; letter-spacing: 0; }
  .brand small { display: none; }
  .brand-mark { width: 34px; height: 34px; }
  .site-header #site-nav { flex: 1 0 100%; padding: 10px 0 16px; display: flex; gap: 8px; flex-wrap: wrap; }
  .site-header #site-nav > a:not([hidden]) { display: inline-flex; min-height: 44px; padding: 8px 12px; font-size: 16px; }
  .js .nav-toggle { display: inline-flex; align-items: center; min-height: 44px; background: white; border: 1px solid var(--line); border-radius: 8px; color: var(--ink); padding: 8px 14px; }
  .js .site-header #site-nav:not([data-open]) { display: none; }
  .public-hero { padding: 28px 0 24px; }
  .public-hero h1 { font-size: 32px; }
  .public-hero p { font-size: 16px; margin: 12px 0; }
  .home-search { grid-template-columns: 1fr 1fr; margin-top: 20px; }
  .home-keyword { grid-column: 1 / -1; }
  .home-search .button { grid-column: auto; align-self: end; min-height: 48px; padding: 0 12px; }
  .snapshot-card { padding: 16px; gap: 0; }
  .snapshot-card > span, .snapshot-card > strong { display: inline; grid-column: auto; }
  .snapshot-card > strong { text-align: right; font-size: 16px; }
  .snapshot-card > p { grid-column: 1 / -1; font-size: 14px; }
  .snapshot-card dl { grid-column: 1 / -1; grid-row: auto; width: 100%; margin-top: 10px; gap: 20px; }
  .snapshot-card dl > div { display: flex; align-items: baseline; justify-content: space-between; gap: 8px; border: 0; padding: 0; }
  .snapshot-card dd { font-size: 18px; }
  .browse-hub { padding: 30px 0; }
  .browse-hub-head { display: block; }
  .browse-hub-head h2 { font-size: 26px; }
  .browse-hub-head p { font-size: 14px; }
  .disease-grid { grid-template-columns: repeat(2, minmax(0, 1fr)); gap: 8px; }
  .disease-card { padding: 13px; min-height: 88px; gap: 4px; }
  .disease-card strong { font-size: 16px; }
  .disease-card b { display: none; }
  .disease-card small { font-size: 14px; }
  .region-list { grid-template-columns: 1fr 1fr; }
  .region-list a { padding: 12px; gap: 4px; }
  .region-list .region-more { grid-column: 1 / -1; }
  .region-browse-grid, .drug-browse-grid { gap: 20px; }
  .topic-hero { padding: 24px 0; }
  .topic-hero h1 { font-size: 30px; }
  .topic-hero .lead { font-size: 16px; }
  .topic-summary div { padding: 12px 10px; }
  .topic-summary dd { font-size: 20px; }
  .topic-summary div:last-child dd { font-size: 14px; }
  .topic-layout { gap: 20px; padding-top: 20px; }
  .topic-sidebar-head { padding: 10px 14px; }
  .topic-search-card { padding: 20px 16px; }
  .topic-search-card h2 { font-size: 22px; }
  .topic-search-form { grid-template-columns: 1fr 1fr; }
  .topic-search-form label:first-of-type { grid-column: 1 / -1; }
  .topic-search-form .button { min-height: 48px; padding: 0 10px; }
  .subtopic-grid { grid-template-columns: repeat(2, minmax(0, 1fr)); }
  .subtopic-card { padding: 12px; gap: 5px; }
  .subtopic-card b { display: none; }
  .topic-result-card { padding: 18px; }
  .record-link { position: static; margin-top: 8px; }
  .topic-result-card h3 { font-size: 18px; }
  .result-card dl div { grid-template-columns: 1fr; gap: 2px; }
  .result-heading h2 { font-size: 26px; }
  .search-hero { padding: 28px 0; }
  .search-hero h1 { font-size: 30px; }
  .structured-search { padding: 16px; margin-top: 20px; }
  .search-filter-group { grid-template-columns: 1fr 1fr; }
  .search-filter-primary .search-input, .search-filter-primary label,
  .search-filter-location .location-input { grid-column: 1 / -1; }
  .search-filter-more { grid-template-columns: 1fr; }
  .search-actions { flex-wrap: wrap; gap: 8px; }
  .search-actions > a { min-height: 44px; display: flex; align-items: center; }
  .results-section { padding: 28px 0; }
  .pagination { gap: 12px; font-size: 14px; }
  .pagination a { padding: 8px 12px; }
  .trial-detail-page .detail-head { padding: 24px 0; }
  .trial-detail-page .detail-head h1 { font-size: 26px; line-height: 1.5; }
  .trial-detail-page .detail-illustration { display: none; }
  .trial-detail-page .breadcrumbs, .trial-detail-page .detail-meta { font-size: 14px; }
  .trial-detail-page .hero-facts dt { font-size: 14px; }
  .trial-detail-page .hero-facts dd { font-size: 16px; }
  .detail-quick-actions { gap: 10px; }
  .detail-quick-actions .button { padding: 0 14px; }
  .trial-detail-page .detail-aside { display: block; }
  .trial-detail-page .overview-section .fact-grid > div { grid-template-columns: 85px minmax(0, 1fr); }
  .trial-detail-page .patient-path { padding: 16px; gap: 8px; }
  .trial-detail-page .snapshot-warning a { min-height: 44px; display: inline-flex; align-items: center; }
  .page-section { padding: 32px 0; }
  .page-section h1 { font-size: 28px; }
  .page-section form { display: flex; flex-wrap: wrap; gap: 12px; }
  .notice { padding: 16px; }
  .about-illustration { display: none; }
  .site-footer { margin-top: 40px; }
}