:root{--navy:#0b2742;--teal:#087c75;--teal-dark:#05645f;--ink:#20344a;--muted:#607083;--line:#dce5e7;--soft:#f2f7f7;--cream:#fff8e8;--white:#fff;--shadow:0 18px 50px rgba(11,39,66,.09);font-family:Inter,"PingFang SC","Microsoft YaHei",system-ui,sans-serif;color:var(--ink);background:#fff;font-synthesis:none}
*{box-sizing:border-box}[hidden]{display:none!important}html{scroll-behavior:smooth}body{margin:0;line-height:1.65}a{color:var(--teal);text-decoration:none}a:hover{text-decoration:underline}button,input,select{font:inherit}.shell{width:min(1160px,calc(100% - 40px));margin-inline:auto}.narrow{max-width:760px}.skip-link{position:fixed;left:12px;top:-80px;z-index:20;background:var(--navy);color:#fff;padding:10px 14px}.skip-link:focus{top:12px}.sr-only{position:absolute;width:1px;height:1px;overflow:hidden;clip:rect(0,0,0,0)}
.site-header{height:76px;border-bottom:1px solid var(--line);background:rgba(255,255,255,.96);position:relative;z-index:10}.nav-row{height:100%;display:flex;align-items:center;justify-content:space-between;gap:24px}.brand{display:flex;align-items:center;gap:11px;color:var(--navy)}.brand:hover{text-decoration:none}.brand-mark{width:39px;height:39px;border-radius:11px;background:var(--teal);color:#fff;display:grid;place-items:center;font-size:21px;font-weight:800}.brand span:last-child{display:flex;flex-direction:column;line-height:1.2}.brand strong{letter-spacing:.04em}.brand small{font-size:11px;color:var(--muted);margin-top:4px}.site-header nav{display:flex;align-items:center;gap:24px}.site-header nav>a:not(.button){color:var(--ink);font-size:14px}
.button{display:inline-flex;align-items:center;justify-content:center;min-height:46px;padding:0 22px;border:0;border-radius:8px;background:var(--teal);color:#fff;font-weight:700;cursor:pointer;box-shadow:0 7px 18px rgba(8,124,117,.16)}.button:hover{background:var(--teal-dark);text-decoration:none}.button-small{min-height:38px;padding:0 16px}.button-ghost{background:#fff;color:var(--teal);border:1px solid var(--teal);box-shadow:none}.eyebrow{display:block;color:var(--teal);font-weight:800;font-size:12px;letter-spacing:.14em;text-transform:uppercase;margin-bottom:9px}h1,h2,h3{color:var(--navy);line-height:1.25;margin:0 0 14px}h1{font-size:clamp(34px,5vw,58px);letter-spacing:-.035em}h2{font-size:clamp(26px,3vw,38px);letter-spacing:-.02em}h3{font-size:20px}.muted{color:var(--muted)}
.site-footer{margin-top:90px;background:var(--navy);color:#cbd7df;padding:44px 0}.site-footer strong{color:#fff;font-size:18px}.site-footer p{font-size:13px;margin:8px 0}.footer-grid{display:grid;grid-template-columns:1fr 1fr;gap:40px}.footer-grid>div:last-child{text-align:right}
.auth-section{min-height:calc(100vh - 250px);padding:74px 0;display:grid;grid-template-columns:minmax(0,620px) 1fr;gap:60px;align-items:center}.auth-card{border:1px solid var(--line);border-radius:18px;padding:42px;background:#fff;box-shadow:var(--shadow)}.auth-card h1{font-size:38px}.auth-aside{padding:38px;border-left:4px solid var(--teal);background:var(--soft);border-radius:0 14px 14px 0}.auth-aside h2{font-size:24px}.stack-form{display:grid;gap:18px;margin-top:28px}.stack-form label{display:grid;gap:6px;font-size:14px;font-weight:700;color:var(--navy)}.stack-form input,.search-form input,.search-form select{width:100%;border:1px solid #bdcbd0;border-radius:8px;background:#fff;min-height:48px;padding:10px 13px;color:var(--ink);outline:none}.stack-form input:focus,.search-form input:focus,.search-form select:focus{border-color:var(--teal);box-shadow:0 0 0 3px rgba(8,124,117,.12)}.stack-form small{font-weight:400;color:var(--muted)}.stack-form .button{margin-top:5px}.form-foot{text-align:center;color:var(--muted);font-size:14px}.trap{position:absolute;left:-9999px}.alert{border-radius:8px;padding:12px 14px;margin:18px 0;font-size:14px}.alert-error{background:#fff1f1;color:#8c2626;border:1px solid #f1c4c4}.alert-success{background:#eaf8f5;color:#075e58;border:1px solid #bee4dc}.check-list{list-style:none;padding:0;margin:18px 0 0;display:grid;gap:12px}.check-list li{padding-left:26px;position:relative}.check-list li:before{content:"✓";position:absolute;left:0;color:var(--teal);font-weight:900}
.search-hero{padding:62px 0;background:linear-gradient(135deg,#f0f8f7 0,#fbfdfd 58%,#eef5f7 100%);border-bottom:1px solid var(--line)}.search-hero h1{font-size:44px}.search-hero>div>p{color:var(--muted);margin-top:0}.search-form{display:grid;grid-template-columns:repeat(4,minmax(0,1fr));gap:12px;align-items:end;margin-top:28px;padding:17px;background:rgba(255,255,255,.9);border:1px solid var(--line);border-radius:12px;box-shadow:var(--shadow)}.search-form label{display:grid;gap:5px;color:var(--muted);font-size:12px;font-weight:700}.search-form .search-input{grid-column:span 2}.search-form .location-input{grid-column:span 2}.search-actions{display:flex;align-items:center;gap:18px}.search-actions .button{min-width:110px}.results-section{padding:52px 0}.result-heading{display:flex;align-items:end;justify-content:space-between;border-bottom:1px solid var(--line);padding-bottom:21px}.result-heading h2{font-size:30px;margin:0}.quota-note{color:var(--muted);font-size:13px}.result-list{display:grid;gap:16px;margin-top:24px}.result-card{border:1px solid var(--line);border-radius:12px;padding:24px;background:#fff;transition:.18s ease}.result-card:hover{border-color:#a9c9c7;box-shadow:0 10px 30px rgba(11,39,66,.07)}.result-meta{display:flex;align-items:center;gap:12px;color:var(--muted);font-size:13px;margin-bottom:9px}.trial-id{font-weight:900;letter-spacing:.03em}.status-pill{padding:3px 9px;border-radius:999px;background:#e7f6f3;color:#066a64}.result-card h3 a{color:var(--navy)}.result-card dl{margin:18px 0;display:grid;gap:8px}.result-card dl div{display:grid;grid-template-columns:76px 1fr;gap:10px}.result-card dt{font-size:13px;color:var(--muted)}.result-card dd{margin:0;font-size:14px}.card-actions{display:flex;gap:22px;font-size:14px;font-weight:700}.pagination{display:flex;justify-content:center;align-items:center;gap:25px;margin-top:34px}.empty-state{text-align:center;padding:65px 24px;border:1px dashed #b9c7cd;border-radius:13px;background:#fbfdfd}.empty-state h1{font-size:42px}.empty-state h3{font-size:24px}
.page-section{padding:75px 0;min-height:55vh}.page-section h1{font-size:48px}.metric-card{padding:28px;border:1px solid var(--line);border-radius:14px;background:var(--soft);margin:28px 0}.metric-card span{display:block;color:var(--muted)}.metric-card strong{font-size:38px;color:var(--navy)}.metric-card p{margin-bottom:0}.notice{border-left:4px solid var(--teal);padding:20px 24px;margin:28px 0;background:#fafcfc}.notice h2{font-size:23px}
@media(max-width:850px){.site-header nav>a:nth-child(-n+2){display:none}.auth-section{grid-template-columns:1fr;gap:24px;padding:44px 0}.auth-aside{order:-1}.search-form{grid-template-columns:1fr 1fr}.search-form .search-input,.search-form .location-input{grid-column:1/-1}.search-form .button{width:100%}.footer-grid{grid-template-columns:1fr}.footer-grid>div:last-child{text-align:left}}
@media(max-width:560px){.shell{width:min(100% - 26px,1160px)}.site-header{height:66px}.brand small{display:none}.site-header nav{gap:10px}.site-header nav>a:not(.button){display:none}.auth-card{padding:26px 20px}.auth-card h1{font-size:31px}.search-hero{padding:40px 0}.search-hero h1{font-size:35px}.search-form{grid-template-columns:1fr}.search-form .search-input,.search-form .location-input{grid-column:auto}.search-actions{justify-content:space-between}.result-heading{display:block}.result-card{padding:19px}.result-meta{flex-wrap:wrap}.result-card dl div{grid-template-columns:1fr;gap:1px}.footer-grid{gap:15px}}
.public-hero{padding:88px 0 74px;background:radial-gradient(circle at 80% 20%,rgba(8,124,117,.11),transparent 34%),linear-gradient(135deg,#f4faf9,#fff 65%)}.hero-grid{display:grid;grid-template-columns:minmax(0,1.5fr) minmax(320px,.8fr);gap:72px;align-items:center}.public-hero p{font-size:18px;color:var(--muted);max-width:670px}.hero-actions{display:flex;align-items:center;gap:26px;margin-top:31px}.text-link{font-weight:800}.snapshot-card{border:1px solid var(--line);border-radius:18px;background:#fff;padding:30px;box-shadow:var(--shadow)}.snapshot-card>span{font-size:12px;color:var(--muted);font-weight:700}.snapshot-card>strong{display:block;font-size:31px;color:var(--navy);margin:3px 0}.snapshot-card>p{font-size:13px}.snapshot-card dl{display:grid;grid-template-columns:repeat(3,1fr);gap:8px;margin:25px 0 0}.snapshot-card dl div{border-top:2px solid var(--teal);padding-top:8px}.snapshot-card dt{font-size:11px;color:var(--muted)}.snapshot-card dd{font-size:21px;font-weight:800;color:var(--navy);margin:0}.trust-strip{display:grid;grid-template-columns:repeat(3,1fr);border:1px solid var(--line);border-radius:14px;margin-top:-24px;background:#fff;box-shadow:var(--shadow)}.trust-strip>div{padding:24px 28px;border-right:1px solid var(--line)}.trust-strip>div:last-child{border:0}.trust-strip strong,.trust-strip span{display:block}.trust-strip strong{color:var(--navy)}.trust-strip span{font-size:12px;color:var(--muted);margin-top:4px}.topic-section{padding:100px 0 80px}.section-head{display:grid;grid-template-columns:1fr 1fr;gap:40px;align-items:end}.section-head>p{color:var(--muted)}.topic-columns{display:grid;grid-template-columns:1fr 1fr;gap:25px;margin-top:34px}.topic-columns>div{border:1px solid var(--line);border-radius:13px;padding:26px}.topic-columns ul{list-style:none;padding:0;margin:0}.topic-columns li{display:flex;justify-content:space-between;gap:20px;padding:10px 0;border-bottom:1px solid #edf1f2}.topic-columns li:last-child{border:0}.topic-columns li span{color:var(--muted);font-size:13px}.boundary-section{padding:72px 0;background:var(--soft)}.boundary-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:36px}.boundary-grid p{margin:0;padding-top:15px;border-top:2px solid var(--teal)}
.detail-head{padding:57px 0 45px;background:linear-gradient(135deg,#f2f8f8,#fff);border-bottom:1px solid var(--line)}.narrow-detail{max-width:1040px}.breadcrumbs{display:flex;gap:9px;color:var(--muted);font-size:12px;margin-bottom:26px}.detail-meta{display:flex;gap:12px;align-items:center;flex-wrap:wrap;margin-bottom:15px}.detail-head h1{font-size:clamp(32px,4.5vw,52px);max-width:950px}.detail-head .lead{font-size:18px;color:var(--muted);max-width:850px}.snapshot-warning{margin-top:30px;padding:17px 21px;background:var(--cream);border:1px solid #ecd9a9;border-radius:10px}.snapshot-warning strong{color:#724600}.snapshot-warning p{display:inline;margin-left:8px;font-size:14px}.detail-layout{display:grid;grid-template-columns:minmax(0,1fr) 295px;gap:45px;padding-top:45px}.detail-content>h2,.detail-content>section>h2{font-size:27px;margin-top:42px;padding-bottom:10px;border-bottom:1px solid var(--line)}.detail-content>h2:first-child{margin-top:0}.fact-grid{display:grid;grid-template-columns:1fr 1fr;margin:0;border-top:1px solid var(--line)}.fact-grid>div{padding:14px 16px;border-bottom:1px solid var(--line)}.fact-grid>div:nth-child(odd){border-right:1px solid var(--line)}.fact-grid dt{font-size:12px;color:var(--muted)}.fact-grid dd{margin:4px 0 0;color:var(--navy)}.fact-grid.compact{font-size:14px}.prose{white-space:normal;line-height:1.85;font-size:15px}details{border:1px solid var(--line);border-radius:10px;margin:12px 0}summary{padding:14px 17px;cursor:pointer;font-weight:800;color:var(--navy);background:var(--soft)}details .prose{padding:18px}.item-block{border-left:3px solid var(--teal);padding:5px 0 5px 18px;margin:17px 0}.item-block h3{font-size:17px}.endpoint-list{padding-left:22px}.endpoint-list li{padding:12px 0 12px 6px;border-bottom:1px solid var(--line)}.endpoint-list span{display:block;font-size:13px;color:var(--muted);margin-top:4px}.detail-aside{position:relative}.aside-card{position:sticky;top:20px;border:1px solid var(--line);border-radius:13px;padding:23px;margin-bottom:18px}.aside-card h2{font-size:21px}.aside-card p{font-size:13px;color:var(--muted)}.aside-card .button{width:100%;font-size:14px}.muted-card{position:static;background:var(--soft)}.topic-results{padding-top:35px;max-width:970px}.topic-limit{text-align:center;color:var(--muted);margin-top:35px}.article-page{padding:55px 0}.article-page h2{font-size:27px;margin-top:38px}.article-page p{font-size:16px;line-height:1.9}.article-page h2:first-child{margin-top:0}
@media(max-width:850px){.hero-grid{grid-template-columns:1fr;gap:35px}.trust-strip{grid-template-columns:1fr;margin-top:20px}.trust-strip>div{border-right:0;border-bottom:1px solid var(--line)}.topic-columns,.section-head,.boundary-grid{grid-template-columns:1fr}.detail-layout{grid-template-columns:1fr}.detail-aside{display:grid;grid-template-columns:1fr 1fr;gap:15px}.aside-card{position:static;margin:0}.snapshot-warning p{display:block;margin:6px 0 0}}
@media(max-width:560px){.public-hero{padding:50px 0}.public-hero h1{font-size:39px}.hero-actions{align-items:flex-start;flex-direction:column;gap:14px}.snapshot-card dl{grid-template-columns:1fr}.topic-section{padding:65px 0}.fact-grid{grid-template-columns:1fr}.fact-grid>div:nth-child(odd){border-right:0}.detail-aside{grid-template-columns:1fr}.detail-head{padding:38px 0}.detail-head h1{font-size:32px}}
/* Keep the brand and access controls on one line even at 320 CSS pixels. */
@media(max-width:560px){.nav-row{gap:8px}.brand{gap:8px;min-width:0}.brand-mark{width:32px;height:32px;flex:0 0 32px;font-size:19px}.brand strong{font-size:14px;letter-spacing:0;white-space:nowrap}.site-header nav{flex-shrink:0;gap:8px}.site-header nav>a{white-space:nowrap}.site-header .button-small{padding:0 10px;font-size:13px}.site-header nav>a[href="/login"]{display:inline;font-size:13px}}
.site-footer a.preview-lock-link{color:#bde2dd;text-decoration:underline;text-underline-offset:3px}

/* Data-boundary page: make the non-negotiable caveats scannable instead of a text wall. */
.about-hero{padding:62px 0;background:radial-gradient(circle at 82% 18%,rgba(8,124,117,.16),transparent 28%),linear-gradient(135deg,#f3f9f8,#fff 68%);border-bottom:1px solid var(--line)}
.about-hero-grid{display:grid;grid-template-columns:minmax(0,1.15fr) minmax(300px,.65fr);gap:70px;align-items:center}
.about-intro h1{max-width:720px}.about-intro .lead{max-width:680px;font-size:18px;color:var(--muted)}
.about-facts{display:flex;flex-wrap:wrap;gap:10px;margin-top:29px}.about-facts span{display:flex;flex-direction:column;min-width:145px;padding:13px 16px;border:1px solid rgba(8,124,117,.2);border-radius:11px;background:rgba(255,255,255,.78);font-size:12px;color:var(--muted)}.about-facts strong{font-size:17px;color:var(--navy)}
.about-illustration{margin:0;border-radius:22px;overflow:hidden;background:#e8f3f1;box-shadow:var(--shadow);aspect-ratio:1}.about-illustration img{display:block;width:100%;height:100%;object-fit:cover}
.about-guide{padding:78px 0 18px}.about-section-head{display:grid;grid-template-columns:1fr 1fr;gap:45px;align-items:end;margin-bottom:31px}.about-section-head h2{margin:0}.about-section-head>p{max-width:470px;margin:0;color:var(--muted)}
.about-card-grid{display:grid;grid-template-columns:1fr 1fr;gap:18px}.about-card{position:relative;min-height:205px;padding:28px 30px 27px 78px;border:1px solid var(--line);border-radius:16px;background:#fff;box-shadow:0 12px 36px rgba(11,39,66,.055)}.about-card-index{position:absolute;left:27px;top:29px;color:var(--teal);font-size:12px;font-weight:900;letter-spacing:.12em}.about-card h3{font-size:23px}.about-card p{margin:0;color:var(--muted);font-size:15px;line-height:1.85}
.about-card-wide{grid-column:1/-1;min-height:auto;display:grid;grid-template-columns:minmax(0,1fr) auto;gap:45px;align-items:center;padding-right:30px;background:linear-gradient(110deg,#eef7f5,#fff)}.about-actions{display:flex;align-items:center;gap:21px;white-space:nowrap}
@media(max-width:850px){.about-hero-grid{grid-template-columns:1fr;gap:32px}.about-illustration{max-width:430px}.about-section-head{grid-template-columns:1fr}.about-card-wide{grid-template-columns:1fr}.about-actions{white-space:normal}}
@media(max-width:560px){.public-hero h1{font-size:35px}.about-hero{padding:42px 0}.about-hero-grid{gap:26px}.about-intro h1{font-size:37px}.about-intro .lead{font-size:16px}.about-facts{display:grid;grid-template-columns:1fr 1fr}.about-facts span{min-width:0}.about-facts span:last-child{grid-column:1/-1}.about-illustration{border-radius:16px}.about-guide{padding-top:52px}.about-section-head{gap:10px}.about-card-grid{grid-template-columns:1fr}.about-card,.about-card-wide{grid-column:auto;min-height:auto;padding:25px 23px 24px 65px}.about-card-index{left:22px;top:27px}.about-card h3{font-size:21px}.about-card-wide{gap:22px}.about-actions{align-items:flex-start;flex-direction:column;gap:13px}}

/* Public launch filing links. */
.filing-links { display: flex; flex-wrap: wrap; gap: 8px 18px; margin-top: 12px; font-size: 12px; }
.filing-links a { display: inline-flex; align-items: center; gap: 5px; overflow-wrap: anywhere; }
.filing-links img { flex: 0 0 18px; width: 18px; height: 18px; }

.browse-chips{display:flex;flex-wrap:wrap;gap:10px;margin:20px 0}.browse-chips a{display:inline-flex;gap:8px;align-items:center;border:1px solid var(--line);border-radius:9px;padding:10px 14px;background:white}.browse-chips a[aria-current]{background:var(--teal);color:white}.browse-chips small{opacity:.75}.browse-panel{border:1px solid var(--line);border-radius:14px;padding:24px;margin:24px 0;background:var(--soft)}.browse-panel p{color:var(--muted)}.browse-search{display:flex;align-items:end;gap:14px}.browse-search label{flex:1}.browse-search input{display:block;width:100%;margin-top:8px;padding:12px;border:1px solid var(--line);border-radius:8px}.topic-columns>div:first-child ul{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:0 20px}@media(max-width:560px){.browse-search{align-items:stretch;flex-direction:column}.topic-columns>div:first-child ul{grid-template-columns:1fr}.browse-panel{padding:16px}}

/* Hierarchical public browsing. */
.browse-hub{padding:96px 0 88px}.browse-hub-head{display:grid;grid-template-columns:minmax(0,1fr) 440px;gap:70px;align-items:end;margin-bottom:34px}.browse-hub-head p{margin:0;color:var(--muted)}
.disease-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:12px}.disease-card{min-height:108px;display:grid;grid-template-columns:38px 1fr auto;align-items:center;gap:14px;padding:20px;border:1px solid var(--line);border-radius:14px;background:#fff;color:var(--navy);transition:.18s ease}.disease-card:hover{border-color:#9bc7c3;box-shadow:0 12px 32px rgba(11,39,66,.08);text-decoration:none;transform:translateY(-2px)}.disease-card-index{align-self:start;color:#75a09d;font-size:11px;font-weight:800;letter-spacing:.08em}.disease-card>span:nth-child(2){display:flex;flex-direction:column;gap:5px}.disease-card strong{font-size:16px}.disease-card small{font-size:12px;color:var(--muted)}.disease-card b{font-size:18px;color:var(--teal)}
.drug-browse-section{padding:76px 0;background:var(--soft);border-block:1px solid var(--line)}.drug-browse-grid{display:grid;grid-template-columns:310px 1fr;gap:70px}.drug-browse-grid header p{color:var(--muted);font-size:14px}.drug-list{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:10px}.drug-list a{display:flex;justify-content:space-between;align-items:center;gap:18px;padding:15px 17px;border:1px solid var(--line);border-radius:10px;background:#fff;color:var(--navy)}.drug-list a:hover{border-color:#9bc7c3;text-decoration:none}.drug-list span{white-space:nowrap;color:var(--muted);font-size:12px}
.region-browse-section{padding:76px 0;background:#fff}.region-browse-grid{display:grid;grid-template-columns:310px 1fr;gap:70px}.region-browse-grid header p{color:var(--muted);font-size:14px}.region-list{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:10px}.region-list a{display:flex;justify-content:space-between;align-items:center;gap:12px;padding:15px 16px;border:1px solid var(--line);border-radius:10px;color:var(--navy);background:#fff}.region-list a:hover{border-color:#9bc7c3;background:var(--soft);text-decoration:none}.region-list span{font-size:12px;color:var(--muted);white-space:nowrap}.region-list .region-more{grid-column:span 2;background:var(--navy);color:#fff;border-color:var(--navy)}.region-list .region-more span{color:#bcd0dc}

.topic-page{background:#fbfdfd}.topic-hero{padding:50px 0 44px;background:linear-gradient(120deg,#edf7f5 0,#fff 72%);border-bottom:1px solid var(--line)}.topic-hero-grid{display:grid;grid-template-columns:minmax(0,1fr) 510px;gap:70px;align-items:end}.topic-hero .breadcrumbs{margin-bottom:20px}.topic-hero h1{font-size:clamp(38px,5vw,56px);margin-bottom:8px}.topic-hero .lead{margin:0;color:var(--muted);font-size:17px}.topic-summary{display:grid;grid-template-columns:1fr 1fr 1.35fr;margin:0;border:1px solid var(--line);border-radius:14px;background:rgba(255,255,255,.9);box-shadow:0 10px 30px rgba(11,39,66,.06)}.topic-summary div{padding:18px 20px;border-right:1px solid var(--line)}.topic-summary div:last-child{border:0}.topic-summary dt{font-size:11px;color:var(--muted)}.topic-summary dd{margin:4px 0 0;color:var(--navy);font-size:24px;font-weight:850;line-height:1.2}.topic-summary div:last-child dd{font-size:16px;padding-top:5px}
.topic-layout{display:grid;grid-template-columns:238px minmax(0,1fr);gap:42px;padding-top:44px}.topic-sidebar{align-self:start;position:sticky;top:20px;border:1px solid var(--line);border-radius:14px;background:#fff;overflow:hidden}.topic-sidebar-head{display:flex;justify-content:space-between;align-items:center;padding:17px 18px;border-bottom:1px solid var(--line);background:#f3f8f7}.topic-sidebar-head span{font-weight:850;color:var(--navy)}.topic-sidebar-head a{font-size:12px}.topic-side-nav{display:grid;padding:8px}.topic-side-nav a{display:flex;justify-content:space-between;align-items:center;gap:10px;padding:9px 10px;border-radius:8px;color:var(--ink);font-size:13px;line-height:1.35}.topic-side-nav a:hover{background:var(--soft);text-decoration:none}.topic-side-nav a[aria-current]{background:var(--teal);color:#fff;font-weight:750}.topic-side-nav small{color:inherit;opacity:.65;white-space:nowrap}.topic-main{min-width:0}
.classification-note{display:grid;grid-template-columns:26px 1fr;gap:12px;align-items:start;padding:14px 17px;border:1px solid #ead7aa;border-radius:10px;background:var(--cream)}.classification-note>span{width:22px;height:22px;display:grid;place-items:center;border-radius:50%;background:#8b611f;color:#fff;font-size:12px;font-weight:850}.classification-note p{margin:0;color:#5f5038;font-size:13px}.classification-note strong{display:block;color:#6f4910;margin-bottom:2px}
.topic-block{margin-top:42px}.topic-block-head,.records-head{display:flex;align-items:end;justify-content:space-between;gap:35px;padding-bottom:17px;border-bottom:1px solid var(--line)}.topic-block-head h2,.records-head h2{font-size:29px;margin:0}.topic-block-head p,.records-head p{max-width:360px;margin:0;color:var(--muted);font-size:13px;text-align:right}.subtopic-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:11px;margin-top:20px}.subtopic-card{min-height:88px;display:flex;justify-content:space-between;align-items:center;gap:12px;padding:17px 18px;border:1px solid var(--line);border-radius:12px;background:#fff;color:var(--navy);transition:.18s ease}.subtopic-card>span{display:flex;flex-direction:column;gap:5px}.subtopic-card strong{font-size:15px}.subtopic-card small{color:var(--muted);font-size:12px}.subtopic-card b{color:var(--teal)}.subtopic-card:hover{border-color:#9bc7c3;box-shadow:0 8px 22px rgba(11,39,66,.06);text-decoration:none}.subtopic-card[aria-current]{border-color:var(--teal);background:var(--teal);color:#fff}.subtopic-card[aria-current] small,.subtopic-card[aria-current] b{color:#d9f0ed}
.topic-search-card{display:grid;grid-template-columns:minmax(0,1fr) minmax(330px,.95fr);gap:38px;align-items:center;margin-top:44px;padding:28px 30px;border-radius:16px;background:linear-gradient(125deg,var(--navy),#123c57);box-shadow:0 16px 36px rgba(11,39,66,.14)}.topic-search-card .eyebrow{color:#83d0c9}.topic-search-card h2{margin:0;color:#fff;font-size:24px}.topic-search-card p{margin:7px 0 0;color:#bdd0dc;font-size:13px}.topic-search-form{display:grid;grid-template-columns:1fr auto;gap:9px}.topic-search-form input{min-width:0;min-height:46px;padding:10px 13px;border:1px solid rgba(255,255,255,.24);border-radius:8px;background:#fff;color:var(--ink);font:inherit}.topic-search-form .button{box-shadow:none;background:#0b9188}
.topic-records{margin-top:52px}.records-head p{padding-bottom:4px}.topic-result-card{position:relative;padding-right:170px}.topic-result-card h3{font-size:19px}.topic-result-card dl{margin-bottom:0}.record-link{position:absolute;right:24px;bottom:24px;font-size:13px;font-weight:800}.record-link span{margin-left:5px}.topic-limit{padding:18px;border-radius:10px;background:var(--soft)}

@media(max-width:980px){.disease-grid{grid-template-columns:repeat(2,minmax(0,1fr))}.browse-hub-head,.topic-hero-grid{grid-template-columns:1fr;gap:28px}.topic-summary{max-width:620px}.topic-layout{grid-template-columns:1fr}.topic-sidebar{position:static}.topic-side-nav{display:flex;overflow-x:auto;padding:10px}.topic-side-nav a{flex:0 0 auto}.topic-search-card{grid-template-columns:1fr}.subtopic-grid{grid-template-columns:repeat(2,minmax(0,1fr))}}
@media(max-width:700px){.browse-hub{padding:64px 0}.disease-grid{grid-template-columns:1fr}.disease-card{min-height:88px}.drug-browse-grid,.region-browse-grid{grid-template-columns:1fr;gap:30px}.drug-list{grid-template-columns:1fr}.region-list{grid-template-columns:1fr 1fr}.topic-hero{padding:34px 0}.topic-summary{grid-template-columns:1fr 1fr}.topic-summary div:nth-child(2){border-right:0}.topic-summary div:last-child{grid-column:1/-1;border-top:1px solid var(--line)}.topic-layout{padding-top:25px;gap:25px}.topic-block{margin-top:34px}.topic-block-head,.records-head{display:block}.topic-block-head p,.records-head p{text-align:left;margin-top:8px}.subtopic-grid{grid-template-columns:1fr 1fr}.topic-search-card{padding:23px 20px;gap:22px}.topic-search-form{grid-template-columns:1fr}.topic-result-card{padding-right:19px}.record-link{position:static;display:inline-flex;margin-top:14px}}
@media(max-width:440px){.subtopic-grid{grid-template-columns:1fr}.topic-summary dd{font-size:21px}}

/* Search follows the patient's decision path: condition, location, then study details. */
.structured-search{display:block;padding:20px}.search-filter-group{min-width:0;margin:0;padding:20px 0;border:0;border-bottom:1px solid var(--line);display:grid;grid-template-columns:repeat(4,minmax(0,1fr));gap:12px;align-items:end}.search-filter-group:first-of-type{padding-top:4px}.search-filter-group legend{grid-column:1/-1;width:100%;padding:0 0 10px;color:var(--navy);font-weight:850;font-size:16px}.search-filter-group legend span{display:inline-grid;place-items:center;width:26px;height:26px;margin-right:9px;border-radius:7px;background:var(--soft);color:var(--teal);font-size:11px}.search-filter-group label{display:grid;gap:5px;color:var(--muted);font-size:12px;font-weight:700}.search-filter-primary .search-input{grid-column:span 3}.search-filter-location .location-input{grid-column:span 2}.filter-help{grid-column:1/-1;margin:2px 0 0;color:var(--muted);font-size:12px}.structured-search>.search-actions{padding-top:18px}.structured-search>.search-actions .button{min-width:150px}
@media(max-width:850px){.search-filter-group{grid-template-columns:1fr 1fr}.search-filter-primary .search-input,.search-filter-location .location-input{grid-column:span 1}.region-list .region-more{grid-column:1/-1}}
@media(max-width:560px){.search-filter-group{grid-template-columns:1fr}.search-filter-primary .search-input,.search-filter-location .location-input{grid-column:auto}.structured-search{padding:16px}.region-list{grid-template-columns:1fr}.region-list .region-more{grid-column:auto}}